Real Madrid will kick off their 2025-26 La Liga campaign when they host Osasuna on Tuesday. The hosts finished last season in second place in the league table, just four points behind Barcelona, while Osasuna finished ninth. Both teams are coming off of preseason victories, with Madrid defeating Austrian club WSG Tirol 4-0 and Osasuna topping La Liga 2 side Mirandes 3-0.
Kickoff from Santiago Bernabeu Stadium in Madrid is set for 3 p.m. ET. The hosts are -500 favorites (risk $500 to win $100) on the 90-minute money line in the latest Real Madrid vs. Osasuna odds, while Osasuna are +1000 underdogs. A 90-minute draw is priced at +550, and the over/under for total goals scored is 3.5. Real Madrid’s Vinicius Junior is -165 to score or assist. Before locking in any Real Madrid vs. Osasuna picks or predictions, you need to see what proven SportsLine’s Jon “Buckets” Eimer has to say. New users at bet365 can get $150 in bonus bets instantly with the latest bet365 bonus code:
Eimer finished 2023 as SportsLine’s No. 1 soccer expert, posting a 248-234-12 (+25.93 units) record on SportsLine article picks. Eimer has been red-hot in 2025, posting a profit in multiple leagues, including the Premier League, Champions League, La Liga, and more. Anyone following his soccer betting picks at sportsbooks could have seen huge returns.
Here are Eimer’s best bets for Real Madrid vs. Osasuna on Tuesday:
- Kylian Mbappe anytime goal-scorer (-135)
- Kylian Mbappe 2+ goals (+250)
- Real Madrid over 2.5 goals team total (+100)
Eimer expects Los Blancos to be firing on all cylinders to start the season after they had to settle for second place in league play last year. They can get their 2025-26 campaign off to a hot start against an Osasuna team that lacks depth and didn’t make any big additions during the offseason.
