A series win is at stake as the Toronto Blue Jays face the Pittsburgh Pirates in an interleague clash on Wednesday afternoon. Toronto managed a victory of 7-3 on Tuesday, while the Pirates secured a win of 5-2 on Monday’s opener. The Blue Jays, leading the American League East with a record of 74-53, stand at 32-32 on the road this season. The Pirates, positioned fifth in the National League Central with a record of 53-74, boast a home winning record of 35-30 during 2025.
Game Day Details: First pitch will be thrown at 12:35 p.m. ET. The Blue Jays have dominated the recent matchups, winning eight of their last ten encounters with the Pirates. Currently, Toronto is favored with a money line of -152, according to the latest odds from DraftKings Sportsbook, and the total runs predicted is 8.
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The SportsLine Projection Model simulates each MLB game 10,000 times and enters Week 22 of the 2025 season with a profitable record of 33-24 on high-stakes MLB money-line picks. Following its predictions on MLB betting at sportsbooks has been beneficial, with almost 60 units of profit this season.
As for pitching, Chris Bassitt (11-6, 4.22 ERA) is expected to start for Toronto. This season, he has made 26 appearances, including 25 starts, covering 138.2 innings while allowing 146 hits and 65 earned runs. His latest outing resulted in a no-decision in a 6-5 victory against the Texas Rangers, during which he pitched five innings giving up four hits and three earned runs.
Powering the Blue Jays’ offense is designated hitter George Springer. This season, he has participated in 105 games, hitting .292 with 18 doubles and 20 homers. In Tuesday’s victory over the Pirates, he recorded a performance of 2-for-4 with a homer, two RBIs, and two runs scored.
On the mound for Pittsburgh, right-hander Braxton Ashcraft (3-2, 3.02 ERA) is anticipated to start. He has pitched in 19 games this season, achieving 41.2 innings while allowing 14 earned runs. In his last outing which resulted in a no-decision in a 2-1 defeat against the Cincinnati Reds, he pitched five innings and allowed just one earned run.
Bryan Reynolds, right-fielder for Pittsburgh, is one of the key players to watch. He delivered a solid performance in last Sunday’s match against the Chicago Cubs with a record of 2-for-5 with a double, and continued to perform well in Tuesday’s game against the Blue Jays.
To sum up, SportsLine’s model favors the over for total runs in this game and indicates value on one side of the money line accordingly.
