The 2025 NFL Opening Kickoff Game will take place on Thursday, September 4, with the Philadelphia Eagles hosting the Dallas Cowboys. With the season approaching, fantasy football enthusiasts must start their draft preparations. The NFL offseason mirrors the action of regular season play, with significant roster changes due to trades and the draft. Navigating these changes is essential for crafting a winning fantasy strategy.

Patrick Mahomes, although coming off a less-than-stellar year, remains a top pick among quarterbacks. Understanding where he fits within the QB tiers, as well as identifying draft sleepers, breakouts, and busts for the season will allow players to build a competitive team. SportsLine provides comprehensive resources, including rankings and insights from a team of experienced fantasy analysts.

This guide details the top 150 players for various league types (non-PPR, half-PPR, full-PPR) and highlights significant players to watch. To equip yourself with the necessary tools for a successful draft, head to SportsLine for the complete 2025 Fantasy Football Draft Bible.