As the 2025 college football season launches this Thursday, fans are gearing up for notable matchups involving top teams in the AP preseason rankings. Headlining the action, the top-ranked Texas Longhorns will take on the defending champions, Ohio State, in what promises to be a thrilling game. Additionally, Clemson will host LSU in another anticipated clash. These significant matchups could dramatically impact the Heisman Trophy odds.

The current favorites for the Heisman at Caesars Sportsbook include:

• Arch Manning, Texas QB (+500): Manning is the favorite, and a strong debut against Ohio State could solidify his frontrunner status.
• Garrett Nussmeier, LSU QB (+700): Nussmeier, despite a challenging schedule, has a great shot at winning the award even in the midst of tough games facing LSU.
• Cade Klubnik, Clemson QB (+800): Klubnik needs a victory against LSU to stay relevant in the Heisman conversation.
• Jeremiah Smith, Ohio State WR (+1000): Smith stands as a unique contender, given the shifting dynamics favoring wide receivers.
• LaNorris Sellers, South Carolina QB (+1000): Recently improved odds reflect Sellers’ potential after a strong performance last season.

Keep an Eye on:

• Julian Sayin, Ohio State QB (+1600): As a potential dark horse, Sayin could boost his profile with a standout performance.

• Ty Simpson, Alabama QB (+1600): Simpson’s starting role at Alabama could elevate his odds, especially with significant games ahead.

• CJ Carr, Notre Dame QB (+2800): Carr has the opportunity to make a big impression in his opener against Miami, which could set the tone for his Heisman campaign.