The Dallas Cowboys will visit the Philadelphia Eagles for the 2025 NFL Kickoff Game on Thursday, September 4, with a scheduled kickoff at 8:20 PM ET. The Eagles are favored by 7 points, with an over/under set at 46.5. In daily fantasy tournaments on FanDuel and DraftKings, selecting the right sleepers and planning lineup variety will be crucial for success.

Running back Saquon Barkley performed remarkably during the previous season against the Cowboys, rushing for 233 yards over two games in 2024. Can he be included in your fantasy lineups?

On the Cowboys’ side, George Pickens will make his debut. Is he a dependable pick for this matchup, or should strategists consider DeVonta Smith, A.J. Brown, or CeeDee Lamb instead? Before finalizing any NFL DFS selections for the Eagles vs. Cowboys, be sure to check out Mike McClure’s tips and strategies at SportsLine, where McClure has amassed over $2 million in career winnings.

Among McClure’s top picks is Eagles running back Saquon Barkley, who had an illustrious season in 2024, becoming just the ninth player ever to rush for over 2,000 yards in a single season, concluding with 2,005 yards and 13 touchdowns. In his previous encounters with the Cowboys, he totaled 233 rushing yards and 15 receiving yards. The absence of Micah Parsons due to injury may enhance Barkley’s performance.

Another key selection in McClure’s lineups is quarterback Jalen Hurts, who in 2024 threw for 2,903 yards and 18 touchdowns, as well as enduring a strong playoff performance that included clinching the Super Bowl MVP award. His dual-threat capability adds significant value. When facing the Cowboys previously, Hurts threw for 202 yards, accumulating two touchdowns alongside rushing for an additional 56 yards and two scores.

For more of McClure’s DFS insights, including under-valued players with the potential for outsized performances, visit SportsLine.