The No. 4 Clemson Tigers are set to host the No. 9 LSU Tigers on Saturday in one of the most anticipated matchups on the Week 1 college football schedule. Clemson, led by quarterback Cade Klubnik, finished the 2024 season 10-4, earning a trip to the College Football Playoff. LSU, entering its fourth season under head coach Brian Kelly, comes off a 9-4 campaign and is led by veteran quarterback Garrett Nussmeier. Both quarterbacks are top contenders for the Heisman Trophy.

Kickoff is set for 7:30 p.m. ET at Memorial Stadium in Clemson, S.C. Clemson is favored by 4 points, with the over/under for total points set at 57.5.

Before making any bets, be sure to check Jimmie Kaylor’s expert predictions. Kaylor has a record of 235-152-7 since Week 1 of the 2023 season. His insights are invaluable ahead of this thrilling game.

Why LSU Can Cover

LSU’s offense relies on quarterback Garrett Nussmeier, who threw for over 4,000 yards last season, and supports a deep receiving corps. Defensively, LSU returns eight starters led by linebacker Whit Weeks, who recorded 120 tackles last season.

Why Clemson Can Cover

Clemson boasts quarter Cade Klubnik and features a home advantage in ‘Death Valley’, where they hold a record of 70–5 at home since 2014.

Picks from Jimmie Kaylor

Kaylor’s analysis suggests leaning under on the point total, emphasizing a critical X-factor influencing the spread.

Who will triumph in this epic rivalry? Check out Kaylor’s final picks and analysis exclusively at SportsLine.