The No. 4 Clemson Tigers are set to host the No. 9 LSU Tigers on Saturday in one of the most highly-anticipated matchups on the Week 1 college football schedule. Clemson, leading with quarterback Cade Klubnik, finished the 2024 season with 10 wins and 4 losses, securing a spot in the College Football Playoff. Meanwhile, LSU, under the direction of head coach Brian Kelly, comes off a season ending with a record of 9-4 and is led by veteran quarterback Garrett Nussmeier. Both quarterbacks are key contenders for the Heisman Trophy entering the season.

Kickoff is scheduled for 7:30 p.m. ET at Memorial Stadium in Clemson, S.C. The latest odds show Clemson favored by 4.5 points, with an over/under set at 56.5 points. For comprehensive insights on picks for LSU vs. Clemson, check out what expert Jimmie Kaylor from SportsLine has to offer.

Why LSU can cover: LSU enters the 2025 season with returning talent and strategic transfers, aiming for a national title run. Nussmeier leads an offense supported by standout receivers like Aaron Anderson, Barion Brown, and Chris Hilton Jr. LSU’s offensive line, enhanced by Weston Davis and DJ Chester, looks to assert dominance.

Defensively, LSU regains eight starters, highlighted by linebacker Whit Weeks and cornerback Zy Alexander. Their secondary - featuring Ashton Stamps, Mansoor Delane, and DJ Pickett - is expected to be top-tier in the SEC.

Why Clemson can cover: With immense expectations, Clemson’s renowned Death Valley remains a formidable home ground with a 70-5 record since 2014. Cade Klubnik, a preseason All-ACC selection and last season’s ACC Player of the Year, aligns with receivers Antonio Williams and Bryant Wesco Jr. for an impressive offensive threat.

Clemson’s defense, returning significant sack production, continues to dominate under defensive stars like Peter Woods and T.J. Parker. Expect a balanced and intense showdown. According to expert insights from Jimmie Kaylor, he favors the under on the total points and has identified crucial factors affecting the spread.

So, who will triumph in the Clemson vs. LSU match-up and what pivotal influence will sway the betting line? For ongoing updates, insights, and expert picks following both teams, visit SportsLine.