The reigning Super Bowl champions, the Philadelphia Eagles, are gearing up to kick off their season against the Dallas Cowboys on September 4, 2025. The Eagles ended last season with a remarkable 14-3 record and secured the Super Bowl with a decisive 40-22 victory over Kansas City. Conversely, the Cowboys had a tumultuous previous season, finishing at 7-10 and missing the playoffs, particularly after quarterback Dak Prescott suffered a hamstring injury that sidelined him for most of the year. This upcoming game marks the first Week 1 clash between these rivals since 2000.

The game will commence at 8:20 p.m. ET at Lincoln Financial Field in Philadelphia, with the Eagles currently favored by 7.5 points according to FanDuel Sportsbook. The total points over/under is set at 47.5. For any betting strategies, it’s worthwhile to consult the SportsLine projection model.

Dak Prescott
Imagn Images

The Eagles dominated the previous season’s matchups against the Cowboys, winning both games by a combined score of 75-13. Running back Saquon Barkley led the league in rushing attempts, rushing yards, and rushing yards per game, totaling 2,504 yards through the end of the playoffs. His performance remains crucial against a Cowboys defense that struggled last season in terms of rushing yards allowed. Additionally, quarterback Jalen Hurts made significant contributions in rushing and will look to maintain his momentum this season.

Conversely, the Cowboys are hopeful about a stronger season with Prescott back from injury. They have also added George Pickens, who excelled in big plays last season, as a crucial target alongside CeeDee Lamb. With the Eagles losing key players like cornerback Darius Slay, this game promises to be both competitive and pivotal for both teams.

For the upcoming game, the model suggests leaning towards the total points being above, and one side of the spread hitting nearly 60% of simulations. More predictions and betting strategies can be found at SportsLine.