AFC West rivals will clash on neutral territory as the Kansas City Chiefs take on the Los Angeles Chargers on September 5, 2025, during the NFL Sao Paulo Game in Brazil. The Chiefs, led by Patrick Mahomes, topped their division with a remarkable 15-2 record last season, marking their tenth consecutive playoff appearance. Meanwhile, the Chargers finished the regular season with an 11-6 record, securing a spot in the Wild Card round under head coach Jim Harbaugh.
Kickoff at Neo Quimica Arena in Sao Paulo is scheduled for 8 p.m. ET. Kansas City has dominated the recent meetings between these teams, winning seven straight, and is favored by 3 points in the latest lines. The over/under for total points is set at 45.5. Before making any betting decisions, be sure to consult the insights provided by the SportsLine projection model, which has demonstrated strong performance with NFL predictions.
The model simulates each NFL game 10,000 times and boasts over $7,000 in profits for $100 bettors on through its top-rated NFL picks since inception, boasting a 31-15 record on those selections last season. Now focused on the Chiefs vs. Chargers matchup, find out which side holds the greatest value in the betting spread at SportsLine.
High-caliber players contribute to this matchup: The Chargers excelled at the betting spread last season, finishing 12-5-0 and have performed well against Kansas City recently.
Mahomes’ proficiency in opening week games cannot be overlooked, as he has impressive stats that demonstrate his capability to lead the Chiefs effectively.
For more detailed insights and the latest betting options, visit SportsLine now.
