The Week 1 NFL schedule is approaching and the league has again spread it out over four different days. The latest Week 1 NFL odds list the Eagles at -7.5 against the Cowboys in the 2025 NFL Kickoff Game on Thursday, Sept. 4. The Chiefs are -3 against the Chargers in Brazil on Friday. Thirteen other games are set for that Sunday, with Bears (-1.5) vs. Vikings concluding the slate on Monday Night Football. The highest total of the Week 1 NFL schedule is 50.5 points in Ravens vs. Bills on Sunday Night Football.
Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 1 NFL picks and parlays, you need to see the Week 1 NFL longshot parlay from SportsLine’s proven computer simulation model that pays out well over $4,000 on a $10 bet.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since inception. The model went 31-15 on top-rated picks in 2024. Anyone following its NFL betting picks at sportsbooks could have seen strong returns.
Now that the simulation model has had a chance to digest the Week 1 NFL odds, it’s locked in its betting picks to form a 5-leg NFL parlay that could pay out over $4,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.
Top Week 1 NFL parlay picks
For Week 1, one of the model’s parlay picks is backing the Buccaneers at the alternate line of -7.5 against the Falcons, a bet that returns +255. The standard spread is Bucs -2.5, but the model has spotted an opportunity to go much bigger here.
The Bucs are projected to win nearly 70% of the time and the model’s winning margin is 8 points, leaving plenty of room to play alternate lines. Tampa Bay returns its explosive offensive core, and even drafted Emeka Egbuka to bolster a strong group of receivers for quarterback Baker Mayfield.
Tampa Bay was also elite defensively late in the 2024 season, allowing just 17 points per game in the final seven games of the season. Atlanta has more question marks overall, and SportsLine’s model likes Tampa Bay’s chances of going on the road and grabbing a big season-opening win. See the rest of the picks in the Week 1 NFL parlay here, and new users can check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:
The parlay also includes four additional picks from SportsLine’s computer model, including an anytime touchdown scorer bet that returns +500. You can only see the picks and the full parlay at SportsLine.
