The defending Super Bowl champions, Philadelphia Eagles, kick off their title defense against their historical rivals, the Dallas Cowboys, in the 2025 NFL Kickoff Game scheduled for Thursday, September 4.

Philadelphia dominated the Kansas City Chiefs 40-22 to secure Super Bowl LIX in February. The Cowboys, who finished with a 7-10 record in 2024, made headlines by trading Micah Parsons to the Packers on August 28.

The Eagles, boasting a 14-3 record in 2024 and having reclaimed the NFC East title, strive to become the first team since the Eagles themselves to win consecutive division titles.

Kickoff is set for 8:20 p.m. ET at Lincoln Financial Field in Philadelphia. The Cowboys lead the all-time series with a record of 74-58, including victories in nine of their last fifteen matchups. Currently, Philadelphia is favored by 7.5 points, with an over/under of 47.5 points.

Why the Eagles Can Cover

Veteran quarterback Jalen Hurts is a dual-threat weapon, having thrown for 2,903 yards and 18 touchdowns in 15 games last season, while also rushing for 630 yards and 14 touchdowns. He excelled during the Super Bowl, completing 17 of 22 passes for 221 yards, along with a touchdown.

His key target, A.J. Brown, recorded an impressive 67 receptions for 1,079 yards and seven touchdowns in 2024.

Why the Cowboys Can Cover

On the other hand, Dak Prescott is back and injury-free after missing multiple games last season. With 1,978 passing yards and 11 touchdowns in just eight games, he aims to lead the Cowboys to a turnaround. CeeDee Lamb is the primary receiver, having led the Cowboys last season with 101 catches for 1,194 yards and six touchdowns.

How to Make Cowboys vs. Eagles Picks

For insights on Thursday’s game, Matthew Severance includes significant factors that could influence the spread. Visit SportsLine to see his selections.