The NFL preseason has concluded, and attention shifts to the opening games of the 2025 season. The action kicks off with the Cowboys vs. Eagles in the NFL Kickoff Game on Thursday, September 4, followed by the Chiefs vs. Chargers match in Brazil on Friday. Thirteen games will take place on the following Sunday, including a showdown of the Vikings vs. Bears on Monday.

Key betting lines include the Eagles favored by -7.5 against the Cowboys after the Micah Parsons trade, and the Steelers at -2.5 against the Jets. The Bills are also favored by -1 in their matchup against the Ravens on Sunday Night Football.

Eric Cohen from SportsLine presents exact score predictions to aid in your betting strategy. In reviewing the matches, he predicts the Bills will triumph over the Ravens 26-23, emphasizing that both teams are among the league’s finest.

“In my opinion, these teams are the best in the NFL and we’ll likely see them face off again in the AFC Championship Game,” Cohen elaborated. “I’ll see the Bills finishing the season at 15-2, while I expect the Ravens to take the Super Bowl. The home crowd’s energy in Buffalo is electrifying, likely giving them the edge in this matchup.”

Find more of Cohen’s insights, including a must-bet recommendation for the over on total points across some games this week at SportsLine.