In the NFL, some bettors prefer to place their bets early while others wait until just before kickoff to ensure maximum value. Regardless of your strategy, Week 1 NFL odds are tight, with many games featuring spreads of less than a field goal, such as Chiefs vs. Chargers (+3) and Steelers vs. Jets (+2.5).
On the flip side, there are two notable matchups with spreads over a touchdown, including the Titans, 8-point underdogs against the Broncos as Cam Ward makes his pro debut.
As the season gets underway, stay informed with updates on the latest Week 1 NFL lines. SportsLine’s advanced model, based on 10,000 game simulations, provides valuable betting insights and predictions to help you make the best Week 1 NFL picks. Visit DraftKings Sportsbook to claim new user offers.
Top Betting Predictions for Week 1
The model suggests that the Bengals (-5.5) will cover against the Browns. Despite uncertainty on who will start for Cleveland, Burrow’s prolific past performance—including leading the league in both passing yards and touchdowns last year—strongly favors Cincinnati.
Another prediction highlights the Packers (-2.5) against the Lions, particularly following their acquisition of Parsons, which boosted expectations. The model anticipates a favorable outcome for Green Bay, making them a worthwhile pick against Detroit, which saw offseason changes that may impact their performance.
Full Week 1 NFL Odds and Lines
| Game | Spread | Total | Picks |
|---|---|---|---|
| Cowboys at Eagles (Thursday) | PHI -7.5 | 47.5 | SEE PICKS HERE |
| Chiefs at Chargers (Friday) - in Brazil | KC -3 | 45.5 | SEE PICKS HERE |
| [Bengals at Browns] | CIN -5.5 | 47.5 | SEE PICKS HERE |
Stay tuned for more insights from the SportsLine model on upcoming games!
