The Week 2 schedule for college football features notable clashes, including No. 15 Michigan’s matchup with the 18th-ranked Sooners in Oklahoma, where the Sooners are favorites by 5.5 points. Both teams are prominent in the history of college football championships and victories.

In-state rivalries also feature heavily, such as the long-standing contest between Iowa and Iowa State, where the Cyclones are predicted to win by 3.5 points.

Other significant matchups include:

• LSU vs. Louisiana Tech
• Florida vs. South Florida
• SMU vs. Baylor

Mississippi State is favored to cover 6.5 points at home against Arizona State, and Syracuse holds the same lead against UConn.

Notably, UConn quarterback Joe Fagnano has yet to claim a road victory against a Power 4 opponent, while Syracuse’s Steve Angeli has demonstrated promise in his collegiate career. With the expected performance from both squads, Syracuse is predicted to win with significant margins over the years, outperforming previous encounters with UConn.

Prepare for these matchups and more as the college football landscape continues to evolve.