The Kansas City Chiefs and Los Angeles Chargers kick off their seasons with an AFC West rivalry in the 2025 NFL Sao Paulo Game on Friday. The game, scheduled for 8 p.m. ET at Corinthians Arena, boasts a rich NFL DFS player pool featuring stars like Patrick Mahomes, Travis Kelce, Xavier Worthy, Justin Herbert, and Ladd McConkey. To create winning NFL DFS lineups, owners must balance high-priced players with valuable budget options. Who are the standout sleepers for this matchup?

Identifying inexpensive but high-potential players is crucial for a successful NFL DFS strategy, especially in Showdown formats. Should you focus on big names like Mahomes, Kelce, or Herbert for your DFS lineups in the 2025 NFL Sao Paulo Game? Before finalizing your picks on platforms like DraftKings and FanDuel, check out the expert DFS lineup advice from Jimmie Kaylor, who has a strong track record in the DFS community.

Kaylor has found success in past competitions, notably winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest in 2022. With nearly ten years of experience covering the NFL and college football, plus his experience as a former college and NFL player, he combines knowledge and firsthand experience in his fantasy analyses.

To learn about other essential DFS picks for the Chiefs vs. Chargers matchup, refer to SportsLine for updates and strategies. Can you uncover the undervalued player poised for a breakout in this game? Only time will tell, but ensuring you make informed decisions is the key.