The Dallas Cowboys are set to face off against the Philadelphia Eagles in the 2025 NFL Kickoff Game on Thursday, September 4. The game will kick off at Lincoln Financial Field at 8:20 p.m. ET. Currently, the Eagles are favored by 8.5 points on FanDuel, with the over/under set at 47.5.

In anticipation of the event, major stakes are on the line for NFL DFS tournaments and cash games on platforms like FanDuel and DraftKings, especially focusing on sleeper picks.

Eagles running back Saquon Barkley racked up 233 rushing yards in two games against the Cowboys last year. Should he be part of your fantasy lineup for this crucial game?

On the opposite side, George Pickens will make his debut for the Cowboys. Can he be a reliable pick, or should you consider other options? Players like DeVonta Smith, A.J. Brown, or CeeDee Lamb present strong alternatives to weigh.