AFC West rivals will clash on neutral turf as the Kansas City Chiefs face the Los Angeles Chargers in the 2025 NFL Sao Paulo Game in Brazil on Friday, September 5. The Chiefs ended the 2024 season at the top of their division with a 15-2 record, marking their tenth consecutive playoff appearance. Meanwhile, the Chargers finished with an 11-6 record and reached the NFL Wild Card round, with Jim Harbaugh in his inaugural season as head coach of the team.
Kickoff at the Neo Quimica Arena in Sao Paulo is scheduled for 8 p.m. ET. Kansas City has emerged victorious in their last seven encounters against Los Angeles and currently holds a 3-point advantage according to the latest odds. The over/under is set at 45.5 points. Before making any picks for the Chiefs vs. Chargers match, check out the insights from the SportsLine projection model.
The model, which simulates every NFL game 10,000 times, has shown a profit of over $7,000 for $100 bettors on top-rated NFL picks since inception. It finished 31-15 on top-rated selections in 2024, offering strong returns for anyone following its betting advice.
Now, the focus is on the upcoming clash between the Chargers and Chiefs. Here are the odds and some betting lines for the game:
| Chiefs vs. Chargers Spread | Kansas City -3 at DraftKings Sportsbook |
|---|---|
| Chiefs vs. Chargers Over/Under | 45.5 points |
| Chiefs vs. Chargers Money Line | KC -171, LAC +143 |
| Chiefs vs. Chargers Picks | See picks at SportsLine |
| Chiefs vs. Chargers Streaming | Fubo (Try for free) |
Why the Chargers Can Cover
The Chargers had a 12-5-0 record against the spread last season, winning their last three games against AFC teams. They have covered the spread in three of their last four matchups against the Chiefs. Najee Harris, the running back, may be limited due to an eye injury, making the Chargers rely more on their passing game. The Chiefs were ranked 18th in passing defense last year, allowing 218.8 yards per game.
Why the Chiefs Can Cover
Despite their successful season, the Chiefs ended with an 8-9-0 ATS. They did not cover the spread in their last seven games, including a narrow win against the Chargers where they were 4.5-point favorites. However, Mahomes has a solid record in Week 1, throwing for 2,059 yards and 21 touchdowns with only two interceptions across seven such games. He has thrown for a total of 3,270 yards, with 27 touchdowns against the Chargers in his career.
How to Make Chargers vs. Chiefs Picks
For the upcoming NFL Sao Paulo Game, the model favors going under the total and indicates a specific side of the spread offers better value. Check out the full analysis and the model’s picks at SportsLine.
