Cowboys vs. Eagles prediction, odds, spread, time: 2025 NFL Kickoff Game picks, best bets by advanced model
The defending Super Bowl champion Philadelphia Eagles will kick off their season against the Dallas Cowboys on September 4, 2025. Last season, the Eagles finished 14-3 and captured the championship with a decisive 40-22 victory over Kansas City. Meanwhile, Dallas missed the playoffs with a 7-10 record, largely due to quarterback Dak Prescott suffering a season-ending hamstring injury after playing only eight games.
Kickoff from Lincoln Financial Field in Philadelphia is scheduled for 8:20 p.m. ET on September 4. The Eagles are favored by 8.5 points in the latest odds, with a total points over/under set at 47.5. Before placing any bets, ensure you check out the SportsLine projection model.
Betting Line Overview
| Category | Line |
|---|---|
| Spread | Philadelphia -8.5 at DraftKings Sportsbook |
| Over/Under | 47.5 points |
| Money Line | Philadelphia -433, Dallas +335 |
| Picks | See picks at SportsLine |
| Streaming | Fubo (Try for free) |
Why the Eagles Can Cover
In the previous season, the Eagles dominated the Cowboys, winning both matchups decisively and outscoring them 75-13. Running back Saquon Barkley led the league in rushing and was able to exploit a Cowboys defense that ranked poorly in rushing yards allowed. Quarterback Jalen Hurts also contributed significantly, ranking well in rushing statistics.
The Eagles are on a remarkable 11-game home winning streak and have covered six out of their last seven NFC East games. See more at SportsLine.
Why the Cowboys Can Cover
With Prescott back in the lineup, the Cowboys are hopeful for offensive improvements. They’ve also added George Pickens, who had the top yards per reception last season, providing Prescott with a dynamic target alongside star receiver CeeDee Lamb.
The Eagles will face challenges on defense after losing Darius Slay and will feature rookie Andrew Mukuba or inexperience in Sydney Brown. Furthermore, the Cowboys have shown consistency in covering spreads, with a recent record of 5-2 in their last seven games.
Making Your Picks
For this NFL Kickoff Game, the model suggests betting on the over for the point total and points to one side of the spread hitting close to 60% of the time. Discover which side of the Cowboys vs. Eagles spread to support, along with results from the model that posted a strong record in top-rated picks last season.
