The college football games for Week 2 are just around the corner, and it’s time for bettors to analyze the Week 1 outcomes. Teams like Ohio State, TCU, LSU, and Florida State have already made significant impressions. Ohio State, LSU, and Florida State are set for more favorable matchups, whereas TCU will take a breather following a decisive win.

Some noteworthy odds for Week 2 include:

• Oklahoma (-5.5) vs Michigan
• Oregon (-28.5) vs Oklahoma State
• Ole Miss (-10) vs Kentucky

Prior to placing any college football wagers for Week 2, bettors are encouraged to consult the college football betting guide crafted by Bruce Marshall, a renowned Vegas handicapper. For years, Marshall’s expertise was tied to The Gold Sheet, a prominent sports betting newsletter. He has amassed various handicapping titles and is currently working on multiple book projects.

Marshall excelled in his 2024 college football predictions, achieving a record of 64-43 and delivering over 16 units of profit, culminating in his recognition as SportsLine’s leading expert. Anyone who kept track of his picks stood to benefit greatly.

With his Tech Corner analysis that scrutinizes betting trends, Marshall has turned his focus to the latest college football odds for Week 2, assessing each matchup.

Top Predictions for Week 2 Marshall highly recommends backing No. 21 Ole Miss against Kentucky during the Saturday 3:30 PM ET kickoff.

Having both excelled in non-conference contests in Week 1, they dive into SEC competition in a rematch following Kentucky’s upset over Ole Miss last season, which severely hindered the Rebels’ playoff pursuits. Marshall believes Ole Miss is spurred by a revenge motivation and predicts the Rebels (-10) will cover the spread against Kentucky, with the game falling under a total of 50.5.

“This is a revenge opportunity for the Rebels after their previous 20-17 loss to Kentucky as 15-point underdogs last year,” said Marshall. “Lane Kiffin is 7-4-1 against the spread in his last 12 games away from Vaught-Hemingway, while the Wildcats have struggled with a 2-5 spread since mid-2024 after not meeting expectations against Toledo in their opener. Mark Stoops’ team is also On the under at 9-4 since last season.”

Visit SportsLine to view all of Marshall’s betting recommendations.

How to Make Week 2 Picks Marshall has also discovered a key 10-1 ATS trend in one of the other significant Week 2 encounters. To gain insight into every matchup, you can access betting analysis at SportsLine, using promo code CHAMPIONSHIP for your first month at just $1.

What profitable college football wagers can you make this week, and what significant trend should you be aware of regarding one of the biggest games? Refer to the latest odds below and then explore additional information at SportsLine to determine the leading teams from a respected Vegas expert known for his multiple handicapping honors and impressive past seasons.