The Week 1 NFL games are about to commence on Thursday, featuring a slew of tight matchups. Among these are significant games like the Chiefs at Chargers (+3), Rams at Texans (+3), Packers at Lions (+2.5), and 49ers at Seahawks (+2.5). Additionally, there are only two games with spreads exceeding a touchdown: the Titans as 8.5-point underdogs against the Broncos, and likewise, the Cowboys against the Eagles in the primetime season opener.

As you prepare for your bets in the opening week of the 2025 NFL season, it’s crucial to analyze the latest updated odds, as shown below. SportsLine provides insights into betting trends based on a predictive model that has effectively simulated all upcoming games over 10,000 times. This same model generated a profit of over $7,000 for $100 players from its best bets since its inception.

Strong Predictions for Week 1

One of the model’s most confident predictions is that the Bengals will cover the spread (-5.5) against the Browns. Joe Flacco, now 40 years old, has struggled recently against the Bengals and is under pressure to perform better. Last year, Joe Burrow led the league with impressive statistics, solidifying his position behind a strong offensive team that retained its core players.

In another pivotal matchup, the Packers should prevail against the Lions, with the line moving to -2.5 after the Packers secured Micah Parsons during the offseason. The matchup reveals that both teams face significant challenges, particularly the Lions, who lost many key players and struggled to pressure opponents consistently. The model suggests the Packers could cover around 60% of the time based on recent simulations.

For detailed predictions and the latest NFL betting odds, visit SportsLine. Here’s what you need to know about the upcoming games:

Game	Spread	Total	Picks
Cowboys at Eagles	PHI -8.5	47.5	SEE PICKS HERE
Chiefs at Chargers	KC -3	45.5	SEE PICKS HERE