The 2025 NFL regular season commences tonight, featuring the reigning Super Bowl champions, the Philadelphia Eagles, as they welcome the Dallas Cowboys. This Sunday marks the start of Week 1, which includes a special international game in São Paulo, Brazil, pitting the Kansas City Chiefs against the Los Angeles Chargers, along with a notable Sunday Night Football clash between the Baltimore Ravens and the Buffalo Bills. Heavyweight matchups such as the Lions facing the Packers and the 49ers taking on the Seahawks will also unfold, with an additional Monday night showdown between the Vikings and the Bears.

The game with the narrowest spread this week is the matchup between the Dolphins and Colts, while the Broncos vs. Titans will be highlighted as a fan favorite. As bettors consider each of the 16 games on the Week 1 NFL schedule, it’s crucial to review the predictions derived from the SportsLine computer simulation model that has shown high success returns.

Explore the top predictions, including the Commanders likely covering their spread against the Giants, and how to approach your NFL betting strategies effectively.