
Week 2 College Football Predictions: Betting Lines, Odds, and Matchups
An analysis of the top college football games to watch in Week 2 of the 2025 season, with picks and betting insights.
College Football Week 2 Picks: Betting Lines and Matchup Analysis
This week in college football features several crucial games that could influence team standings early in the season. Iowa vs. No. 16 Iowa State will be a key matchup to watch as Iowa looks to continue its winning streak in a highly competitive rivalry.
Key Games:
- No. 6 Oregon vs. Oklahoma State: Oregon comes in with a strong performance expected after a rough start for Oklahoma State’s restructured roster.
- No. 21 Ole Miss against Kentucky: Both teams are seeking to assert their dominance after close games in previous matchups.
- No. 15 Michigan vs. No. 18 Oklahoma: This clash will pit two teams with new quarterbacks against each other in what promises to be a defensive battle.
Betting Insights
You can bet on these games through various sportsbooks that are offering bonuses to new users.
Knowing these factors, bettors will want to pay close attention to the team’s recent performances and potential injuries as they prepare to place their bets.