The second week of college football may not feature high-profile matchups seen in prior weeks, but it’s set to showcase two of the sport’s historic powerhouses. No. 15 Michigan will visit Oklahoma (ranked 18th), with the Sooners being 5.5-point favorites after adjusting from their initial odds of 1.5. Both teams are in the top ranks for total college football titles and victories.

A notable in-state rivalry is set as Iowa faces Iowa State, where the No. 16 Cyclones are favored by 3.5 points in a matchup steeped in history since 1894. Colorado intends to recover against Delaware as heavy favorites, while UNC looks to score against Charlotte as they gear up with a 13.5-point edge.

Before finalizing your Week 2 picks, check out the latest SportsLine predictions. Their method simulates every FBS game approximately 10,000 times, yielding more than $2,000 profit for $100 players over time on their top-tier spread choices.

Key Predictions for Week 2

The model notably favors Mississippi State (+6.5) to cover against Arizona State. Historically, ASU struggles against SEC teams, showing a 0-2 record traveling in this matchup. In their past game against Mississippi State, Arizona needed a significant performance from Cam Skattebo.

Also highlighted is Syracuse (-6.5), expected to maintain dominance over UConn. With insights into quarterback performances and their opposing defenses, this projection indicates that the Orange should comfortably claim victory and perhaps hit the Over (57) marks across a variety of betting scenarios.

Insights into How to Bet this Week

The in-depth model is assessing significant matchups across the board, calling potential upsets involving ranked teams. Check the updated betting odds and insights for informed decisions this week. Additional picks are also available for early access to SportsLine’s premier model, available for a promotion if you sign-up.

Upcoming Noteworthy Games

Full odds and predictions for Week 2 can be found here.

Saturday, September 6 Matches
Illinois vs. Duke (+2.5, 49.5)
Iowa vs. Iowa State (-3.5, 42.5)
Virginia vs. NC State (-3, 5.54)
Texas vs. San Jose State (+37, 52.5)
Clemson vs. Troy (+31.5, 51.5)
And many more.