The Cincinnati Bengals are facing mounting pressure as they head to Cleveland for the kickoff of the 2025 NFL season. After a strong finish to last year, they are looking to start off on the right foot against the Cleveland Browns, who have recently announced Joe Flacco as their starter.

The Bengals are favored by 5.5 points despite Burrow’s 3-5 record against the Browns and Flacco’s long absence from facing Cincinnati since 2022.

Additionally, the Pittsburgh Steelers will meet the New York Jets, with both Aaron Rodgers and Justin Fields in the spotlight. The Steelers come in as 3-point underdogs, and this matchup has a low over/under of 38 points, the lowest of the week.

If you’re considering Week 1 NFL betting picks, be sure to check SportsLine’s proven model, which has simmed every game 10,000 times and generated substantial returns.

The model rates the Washington Commanders highly against the New York Giants. Key players like Jayden Daniels and Terry McLaurin will be instrumental as they attempt to cover a solid spread.

For lucrative betting tips and a comprehensive analysis of NFL betting odds for Week 1, check out SportsLine’s insights here.