Following intense matchups on the first two days, the NFL Week 1 schedule is set for Sunday. Major games include Lions vs. Packers, Bills vs. Ravens, and a Monday night clash between the Vikings and Bears.

The tightest spread is the Dolphins vs. Colts game, and the largest is Broncos vs. Titans. Knowing the outcomes can significantly impact betting decisions.

Before placing any bets, check out the NFL picks based on a computer model that simulates every game 10,000 times. This model has reportedly earned more than $7,000 for $100 players since it started.

Week 1 NFL Score Predictions
The computer model predicts that the Commanders will cover comfortably against the Giants in their season opener, likely sending the game over a total of 45.5 points.

How to Make You Week 1 NFL Computer Picks
The model displays three other preferred picks for Week 1, which includes underdogs winning outright. For detailed predictions and analysis, visit SportsLine now.