The prime-time NFL matchup features the Buffalo Bills against the Baltimore Ravens at Highmark Stadium in Orchard Park, NY. Previously, these teams faced each other in the AFC playoffs, with Buffalo winning that thrilling encounter 27-25.

In this showdown, the spotlight shifts to last seasons’ MVPs, Josh Allen and Lamar Jackson. As we build our lineups on DraftKings and FanDuel, fantasy players must decide between these star quarterbacks.

Other key player picks include running backs Derrick Henry and James Cook. Are they vital components of a winning NFL DFS strategy?

Fantasy expert Mike McClure, known for his impressive modeling and successful DFS strategies, is advising players to consider Jackson for his explosive capabilities and unique skill set.

In 2024, Jackson topped 4,172 passing yards with 41 touchdowns while only throwing four interceptions, enjoying a record-breaking season. On the other hand, Cook displayed his potential by accumulating over 1,000 rushing yards and leading the league in touchdowns.

For those keen on enhancing their DFS picks, the full strategy and additional player recommendations can be found on SportsLine.