The NFL Week 1 schedule is set, with teams eager to secure early victories. The Green Bay Packers, who reached the playoffs last year but lost to the Philadelphia Eagles in the Wild Card Round, will face the Detroit Lions in their season opener on Sunday at 4:25 p.m. ET. Despite their struggles against Detroit (1-6 in their last seven matchups), Green Bay comes in as 2.5-point favorites, according to the latest Week 1 NFL odds.
SportsLine’s model is confidently backing the Packers, who boast a 10-4 record at home over their last 14 games, to cover the spread in a significant number of simulations.
The model is also in favor of the Jaguars (-3.5) to win against the Panthers at home, while the Over (45.5) is predicted to hit in over 60% of simulations for the Giants vs. Commanders game. Other noteworthy betting lines include the Steelers at Jets (+3, 38), Texans at Rams (-3, 43.5), and Ravens at Bills (+1, 50.5).
Before placing bets on your preferred betting sites, don’t forget to check out the top NFL picks provided by SportsLine’s proven model, which has demonstrated strong performance since its inception.
The model successfully predicted a profit of over $7,000 for $100 players on top-tier NFL picks, going 31-15 on such bets in 2024. Following its NFL betting selections could lead to impressive returns.
Week 1 NFL Best Bets:
- Packers (-2.5) vs. Lions
- Over 45.5 points in Giants vs. Commanders
- Jaguars (-3.5) vs. Panthers
Combining these three bets into a Week 1 NFL parlay could yield a return of +595 (risking $100 to win $595) at DraftKings. Place your bet at DraftKings Sportsbook now.
Packers -2.5 vs. Lions
The Lions have been a tough opponent under head coach Dan Campbell, but the Packers have the right lineup to ensure a win on Sunday. The Packers’ offense is spearheaded by running back Josh Jacobs, who had an impressive season last year, rushing for 1,329 yards and 15 touchdowns. In their last encounter with Detroit, Jacobs recorded 66 yards and three touchdowns. SportsLine’s model predicts Jacobs will perform well again, enabling Green Bay to cover the spread in 56% of scenarios.
Giants vs. Commanders: Over 45.5 Points
With veteran quarterback Russell Wilson joining the Giants, the team aims for more offensive stability. Wide receiver Malik Nabers had a standout rookie season, while the Commanders also feature talented players who can make game-changing plays. Trends indicate that the total points have been high in recent Commanders games. The model estimates an average of 53 points for this matchup, making the Over a strong bet in 66% of simulations.
Jaguars -3.5 vs. Panthers
The Panthers have struggled on the road, winning only two of their last 17 games outside of Carolina. They also face challenges historically in Week 1, and in their last meeting with the Jaguars, they suffered a 26-0 defeat. This Sunday, SportsLine’s model believes Jacksonville will effectively disrupt the Panthers’ quarterback, resulting in a 55% cover rate in simulations.
To see more picks for Week 1 by NFL insider Emory Hunt, who holds an impressive 45-24-1 record in his recent predictions, click here.
