The anticipation mounts as the Cincinnati Bengals prepare for their opening match against the Cleveland Browns on Sunday, marking the beginning of the 2025 NFL season. With the Bengals missing playoffs last year despite a strong performance from quarterback Joe Burrow, who’s recorded three wins against Cleveland, the Bengals go into this game as 5.5-point favorites. Meanwhile, the Browns’ Joe Flacco will make his return as starting quarterback after a hiatus since 2022.

In other exciting matchups, the Dolphins are set to face the Colts, with a tight spread of just 1 point, as Daniel Jones makes his debut against Tua Tagovailoa. Additional close matchups include Buccaneers versus Falcons and 49ers against Seahawks, both also forecasted to have narrow outcomes.

To maximize your betting strategy this season, it’s essential to leverage insights from SportsLine’s statistical model, which has shown success with over $7,000 in profit for $100 players on its premium NFL picks since inception. Following its track record of 31-15 on top-rated advice in 2024, this model has targeted five promising bets that could yield a parlay payout of nearly 25-1.

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Top Week 1 NFL Picks

• Washington Commanders (-6.5) are favored to cover against the New York Giants, after a stellar last season that saw them advance to the NFC Championship Game. Jayden Daniels has made considerable strides in consistency, boasting 69% completion over 3,568 yards and 25 touchdowns.

• With Terry McLaurin’s new contract solidifying his spot in the starting lineup, and after winning both previous meetings against the Giants last season, confidence remains high.

This week promises dynamic matchups and lucrative betting options, making it an exciting opening to the NFL season.