The 2025 NFL Week 2 schedule is packed with exciting matchups. Notably, the Philadelphia Eagles face the Kansas City Chiefs in a rematch of Super Bowl LIX, where the Chiefs are slight favorites at +1. Other significant matchups include:
- Commanders vs. Packers (-3.5) on Thursday
- Broncos vs. Colts (+2.5), Bears vs. Lions (-5.5), and Giants vs. Cowboys (-5.5) on Sunday
- Buccaneers vs. Texans (-2.5) and Chargers vs. Raiders (+3.5) on Monday night
Among the games, the Browns vs. Ravens has the widest spread at -10.5 this week.
To gain insights before placing your bets, check out the complete list of NFL picks generated by a computer simulation model that has been successful in making accurate predictions.
The model has raised over $7,000 for $100 players on top-rated NFL picks since its inception. Following its picks since 2024, players have seen considerable success. For Week 2, the model has evaluated NFL odds for all games, revealing key betting insights. See the simulation model’s predictions here.
As you consider your betting strategy for Week 2, remember that the Ravens, led by quarterback Lamar Jackson, are eager to perform well after a close loss against the Bills. Jackson boasted impressive stats, while teammate Derrick Henry also contributed significantly last week. Expect thrilling matches as teams battle it out on the field this week!
