In the opening weeks of the 2025 college football season, South Florida has made waves, shocking both Boise State and Florida. Under the leadership of Alex Golesh, they have emerged as slim contenders for the College Football Playoff. This Saturday, they’ll face Miami in a thrilling top-20 confrontation. Currently, Miami stands as 17.5-point favorites with the over-under set at 57.5, having a historical advantage of 6-1 in past encounters.

Potentially high-stakes games this week include Tennessee against Georgia (spread -3.5) and LSU facing Florida (+7.5). Other matchup highlights cover Texas A&M vs. Notre Dame (-6.5), as well as Arkansas meeting Ole Miss (-7.5). With so many lines in play, what bets yield the best returns?

Insights from Thomas Casale

Thomas Casale, a regular on various sports platforms, brings over 30 years of betting expertise. He has kicked off the season with a solid 5-3 record and a commendable 18-9 in best bets dating from last season. This week, he focuses on Miami, asserting:

“The issue facing the Bulls is the significant gap between them and Miami in terms of toughness. The Hurricanes have a top-notch offensive and defensive line. In their opener against Notre Dame, Miami adeptly dominated, allowing only 93 rushing yards.”

Casale anticipates strong performance from the Canes, suggesting backing them at -17.5. For the complete breakdown of Casale’s expertise and further selections, check the insights at SportsLine.

For what bets to back this week, and to discover which underdog might clinch an unexpected victory, follow Casale’s picks, who has established a strong reputation in college football predictions.