In the first of two Week 2 “Monday Night Football” matchups, the Houston Texans host the Tampa Bay Buccaneers.

The Texans are coming off a disappointing loss to the Los Angeles Rams and looking to level their record at 1-1 while trying to keep pace with the surprising unbeaten Indianapolis Colts in the AFC South. The Buccaneers secured an exciting, comeback victory over the divisional rival Atlanta Falcons in their season opener and aim to move to 2-0 and maintain their lead in the NFC South.

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Both teams will showcase former top-two draft picks under center. It’s a matchup between Baker Mayfield (who was the No. 1 overall pick) and C.J. Stroud (the No. 2 pick). With both aiming for playoff returns, this game is critical for positioning.

Where to watch Texans vs. Buccaneers live

• Date: Monday, Sept. 15 | Time: 7 p.m. ET
• Location: NRG Stadium (Houston)
• TV: ABC/ESPN | Stream: Fubo (Try for free)
• Follow: CBS Sports App
• Odds: Texans -2.5; O/U 42.5 (via DraftKings Sportsbook)

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The Buccaneers picked up a win last week against the Falcons, but their offensive efficiency was not as high as previous seasons, averaging just 4.6 yards per play, with Mayfield completing only 17 of 32 passes for 167 yards but making up for it with three touchdown passes.

However, the Texans have a strong defense capable of pressuring the quarterback and are looking to improve their performance against the Buccaneers’ struggling offensive line. Players like Will Anderson Jr. and Danielle Hunter will pose significant threats.

Ultimately, despite the absence of two key Buccaneers players, the Texans are favored in this matchup at home. Prediction: Texans 20, Buccaneers 17.