The NFL’s Week 3 schedule presents a mix of divisional matchups and inter-conference contests. Notably, the Broncos will face the Chargers, with L.A. currently favored by 2.5 points. The 49ers, also favored at 1.5 points, will battle the Cardinals.

In addition, the Bengals will take on the Vikings (-3), while the Chiefs are set against the Giants (+6.5), and the Ravens will face off against the Lions (+5). These matchups between AFC and NFC teams are not frequent, potentially making them more appealing for predictions this week.

As teams have already played a couple of games this season, sportsbooks have more insights into their relative strengths. Consequently, this week’s bets see broader spreads, with four games displaying lines of at least a touchdown.

Should bettors consider placing their wagers on the Bucs (-7) against the Jets or the Seahawks (-7.5) versus the Saints for Week 3?

Below are the updated lines for Week 3, along with recommendations from SportsLine’s advanced computer model which provides ample betting advice and insights for all NFL matchups.

Check out the Week 3 betting picks below to make informed decisions on your bets. Odds and lines are subject to change, so stay tuned for the latest updates as teams play their games.