The Week 5 college football betting landscape is packed with compelling matches. Notable lines include No. 3 Penn State favored by 3.5 over No. 6 Oregon and No. 5 Georgia at -3 against No. 17 Alabama.

As you prepare your bets, consult the betting guide from renowned Vegas expert Bruce Marshall for insights.

Marshall has a strong track record, excelling in the 2024 season with a 64-43 record, resulting in over 16 units in profit. His latest trend analysis for Week 5 reveals valuable insights.

One key pick highlights Arkansas (+4.5) to cover at home against Notre Dame. Marshall states: “Believe it or not, this is the first-ever meeting,” referencing a past close call with the Cotton Bowl matchups. With trends favoring the Over and a slight edge to Arkansas based on recent stats, this game shapes up to be a highlight.

Top College Football Odds for Week 5:

• Thursday, Sept. 25: Army vs. East Carolina (-4, 53.5)
• Friday, Sept. 26: Florida State vs. Virginia (+7, 59.5)
• Notre Dame vs. Arkansas (+4.5, 64.5)
• Alabama vs. Georgia (-3, 52.5)

Be sure to check the complete odds and predictions for Week 5 at SportsLine!