The NFL’s Week 4 starts with a thrilling ‘Thursday Night Football’ matchup where the Arizona Cardinals will face the Seattle Seahawks. The game kicks off at 8:15 p.m. ET at State Farm Stadium in Glendale, Arizona. Both teams integrate a mix of seasoned stars and emerging talent. Notably, the Seahawks’ Sam Darnold and the Cardinals’ Kyler Murray are prominent in the fantasy football player pool, making them viable options for daily fantasy contests. Other players expected to be highly drafted include Jaxon Smith-Njigba, Kenneth Walker III, Marvin Harrison Jr., Trey McBride, and Trey Benson.

To refine your NFL DFS strategy, prior to finalizing your lineup on platforms like DraftKings and FanDuel, consider checking in on the guidance from Mike McClure, a renowned DFS professional with over $2 million in lifetime earnings. He employs a sophisticated prediction model that evaluates matchups, injury data, and statistical trends to identify the best value players, offering those insights exclusively to SportsLine members.

Top NFL DFS Picks for Seahawks vs. Cardinals
One of McClure’s standout suggestions includes Seattle’s wide receiver Jaxon Smith-Njigba, who registered impressive stats in 2024—a total of 100 receptions for 1,130 yards (averaging 11.3 per catch) and six touchdowns. This performance secured his first Pro Bowl nomination. He has maintained this level of excellence through the opening weeks of 2025 with 22 receptions for 323 yards (14.7 per catch) and a touchdown.

In the Cardinals’ lineup, Trey Benson, a promising rookie, is expected to step up with starting running back James Connor out for the season due to injury. Benson has showcased his skills, averaging 6.0 yards per carry over the past three weeks.

For comprehensive NFL DFS advice and to discover who else to consider for your rosters, visit SportsLine to view McClure’s analysis.