For the first time all season, several teams will be on a bye this week, including the Packers. This week’s matchups offer an intriguing set of predictions ranging from the challenging circumstances of the 49ers, who are contending with multiple injuries, to the Browns’ shift from Joe Flacco to Dillon Gabriel at quarterback.

NFL Week 5 Picks

San Francisco (3-1) at L.A. Rams (3-1)

Thursday, 8:15 p.m. ET (Amazon Prime)

Picking a winner in this matchup is complicated. The 49ers are severely injured, lacking key players such as Brock Purdy and Mac Jones. The Rams are expected to capitalize on this, especially given their formidable defense.

PICK: Rams 24-17 over 49ers.

Cleveland (1-3) vs. Minnesota (2-2) in London

Sunday, 9:30 a.m. ET (NFL Network)

This matchup could feel like football from 1942, with both teams expected to struggle offensively. The Browns will start Dillon Gabriel, which may provide a much-needed spark.

PICK: Browns 19-16 over Vikings.

Other Notable Matches

Houston (1-3) at Baltimore (1-3) - 1 p.m. ET (CBS) Seattle (3-1) at Tampa Bay (3-1) - 4:05 p.m. ET (CBS) Kansas City (2-2) at Jacksonville (3-1) - Monday, 8:15 p.m. ET (ESPN)

Given the injury woes and matchups, Week 5 promises to be a pivotal moment in the NFL season, as teams either step up or fall behind.