
The Week 6 college football slate is brimming with games that will influence the College Football Playoff landscape. Notably, the No. 10 Alabama Crimson Tide are set to take on No. 16 Vanderbilt Commodores. Last season, Vanderbilt shocked Alabama with a 40-35 victory, raising questions about their chances on the road.
The latest odds indicate that Alabama is favored by 10.5 points at home, with a total points over/under set at 56.5. According to SportsLine’s model, Alabama has a 58% chance to cover the spread, having won their last six home games against Vanderbilt.
Meanwhile, North Carolina is projected to cover the +14 spread against Clemson, with the over hitting 59% of the time in matchups between Miami and Florida State. Other noteworthy lines include Wisconsin vs. Michigan (-17.5), Kansas State vs. Baylor (-6.5), and Texas vs. Florida (+6.5).
Before finalizing your Week 6 college football picks, check out SportsLine’s top betting insights.
Week 6 Betting Picks
- Alabama (-10.5) vs. Vanderbilt
- North Carolina (+14) vs. Clemson
- Over 54.5 points in Miami vs. Florida State
Combining these three selections into a parlay could yield a payout of +596 (bet $100 to win $596). Bet now at Caesars Sportsbook.
Alabama vs. Vanderbilt
Alabama recently clinched a win against Georgia, propelled by quarterback Ty Simpson’s impressive stats—276 passing yards and two touchdowns. Defensively, Alabama stifled Georgia, limiting their QB, Gunner Stockton, to merely 130 yards. The Crimson Tide have a 7-3 record against the spread in their last 10 games, while Vanderbilt struggles with a 1-4 ATS record in recent face-offs against Alabama.
North Carolina vs. Clemson
Clemson enters this ACC clash after stumbling in their last two matches, including a home loss to Syracuse (34-21) on September 20. Averaging only 19.8 points per game, Clemson ranks 114th nationally. The team has failed to cover in their last five games and is 1-5 ATS in their latest games against North Carolina. SportsLine’s model backs North Carolina with a 58% probability of covering the spread.
Miami vs. Florida State
In what promises to be an exciting match, Florida State welcomes Miami at 7:30 PM ET. Despite a recent loss to Virginia, Florida State boasts the nation’s best scoring offense, averaging 53 points per game. Meanwhile, Miami scores an average of 36.8 points per game, and the model anticipates this game totaling 60 points, suggesting the over will hit 59% of the time.


