The South Florida Bulls will commence their American Conference journey against the Charlotte 49ers on Friday evening. Charlotte is arriving from a recent defeat against the Rice Owls on September 18, while South Florida is fresh off a commanding victory against South Carolina State with a score of 63-14 on September 20.

Kickoff from Raymond James Stadium in Tampa, Florida, is at 7 p.m. ET. South Florida has an all-time series lead of 2-0, having achieved a victory last season with a score of 59-24 against Charlotte.

Odds and Predictions

The latest odds show the Bulls as 28.5-point favorites, with an over/under of 55.5 points. The SportsLine Projection Model has generated a betting profit for players, exceeding $2,000 on its top college football picks since its inception.

Key Players to Watch

• Byrum Brown, a dual-threat quarterback for South Florida, has thrown for 983 yards and six touchdowns.
  • He will lead the charge against Charlotte.
• Chas Nimrod, who transferred from the Tennessee Volunteers, has made a significant impact with 14 catches for 367 yards this season.
  • He could be a pivotal asset in the matchup.

For Charlotte, quarterback Conner Harrell is also worth keeping an eye on, as he has shown promise with 737 passing yards and four touchdowns this season. His primary target is fellow transfer E. Jai Mason, who has been reliable, with 20 receptions for 308 yards so far.

Check out the college football betting options available to maximize your chances this weekend.