The Buffalo Bills are poised to take complete control of the AFC East when they face the New England Patriots in Sunday Night Football. A win would extend Buffalo’s lead to three games over the second-placed Patriots just five weeks into the season. Following a thrilling 41-40 victory against the Baltimore Ravens in their first game, the Bills have maintained a strong performance. Current forecasts are favorable for Buffalo at -8.5 against the visiting Patriots, even as New England has a historically strong advantage in their 79-51-1 all-time series. Still, the Bills have reciprocated with eight wins out of the last 11 encounters.
As for the remaining Week 5 matchups, fans can look forward to several exciting games including the Vikings clashing with the Browns (+3.5) in London, the Texans battling the Ravens (-1.5), the Raiders against the Colts (-7), the Cowboys facing the Jets (+2.5), Lions meeting Bengals (+10.5), and Monday Night Football featuring Chiefs versus Jaguars (+3.5).
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Top Week 5 NFL Picks
In light of the comprehensive game simulations totaling 10,000 attempts, the model is bullish on the Minnesota Vikings (-3.5, 36) covering against the Cleveland Browns. With Super Bowl hopes on the horizon, the Vikings must secure a win while navigating injuries to key players like starting quarterback J.J. McCarthy (leg), who is expected to sit out again.
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