The Week 5 NFL schedule marks the introduction of byes, which means fewer games to bet on. This focus on select matchups—such as Jets vs. Cowboys and Cardinals vs. Titans—allows for a thorough examination of the betting landscape. The Saints are predicted to cover against the Giants, as their top running game poses issues for New York. The model also forecasts a win for the Cardinals against Tennessee, where they have performed impressively against the AFC in past matchups.
Top Week 5 NFL Predictions
Saints vs. Giants: Saints are favored to cover the spread. The Giants recently lost their key player, creating a disadvantage.
Cardinals vs. Titans: Cardinals are expected to cover the spread as they enter the game with successful previous outings against AFC opponents.
NFL Betting Odds, Lines, Live Spreads
| Game | Spread | Total | Picks |
|---|---|---|---|
| 49ers at Rams (Thursday) | LAR -8.5 | 44.5 | SEE PICKS HERE |
| Vikings vs. Browns | MIN -3.5 | 36.5 | SEE PICKS HERE |
| Texans at Ravens | HOU -1.5 | 40.5 | SEE PICKS HERE |
| Dolphins at Panthers | MIA -1.5 | 44.5 | SEE PICKS HERE |
| Raiders at Colts | IND -7 | 48 | SEE PICKS HERE |
| Giants at Saints | NO -1.5 | 42 | SEE PICKS HERE |
| Cowboys at Jets | DAL -2.5 | 47.5 | SEE PICKS HERE |
| Broncos at Eagles | PHI -3.5 | 43.5 | SEE PICKS HERE |
| Titans at Cardinals | ARI -7.5 | 41.5 | SEE PICKS HERE |
| Buccaneers at Seahawks | SEA -3.5 | 44.5 | SEE PICKS HERE |
| Lions at Bengals | DET -10.5 | 49.5 | SEE PICKS HERE |
| Commanders at Chargers | LAC -2.5 | 48.5 | SEE PICKS HERE |
| Patriots at Bills | BUF -8.5 | 50.5 | SEE PICKS HERE |
| Chiefs at Jaguars (Monday) | KC -3.5 | 46.5 | SEE PICKS HERE |
