Crafting a successful NFL DFS strategy may take various approaches, yet a common method is to target games projected to have the highest point totals when selecting picks and constructing stacks. This week’s highest over/under is set at 49.5 for the Lions vs. Bengals game. Other potential high-scoring competitions include Raiders vs. Colts, Cowboys vs. Jets, and Patriots vs. Bills. Look to include standout players like Jahmyr Gibbs, Jonathan Taylor, and Josh Allen in your lineups.

However, premium players can quickly escalate your salary cap in DFS, making it essential to identify sleeper picks and value opportunities. Should you consider incorporating quarterbacks like Jaxson Dart or Jake Browning into your lineup? Can we expect underperformers such as Ja’Marr Chase to finally deliver on their price tags? Before locking in your lineups on DraftKings or FanDuel, ensure you check out the SportsLine advanced NFL DFS lineup optimizer.

The DFS Optimizer analyzes data from an advanced projection model alongside insights from DFS expert Mike McClure to determine ideal picks for any betting slate. It simulates games 10,000 times to aid players in optimizing their DraftKings or FanDuel lineups while supplying crucial information like injury reports, player projections, and gambling odds.

Currently, the optimizer has pinpointed its top picks for Week 5 of the 2025 NFL season. Check out the rest of its suggested lineups exclusively at SportsLine.

Premier NFL Week 5 DFS Recommendations for Sunday

One notable value selection is Colts QB Daniel Jones ($5,800 on DraftKings and $7,400 on FanDuel). Having started 2025 on a strong note, Jones has thrown for an impressive 1,078 yards, along with four touchdowns and two interceptions in the first quarter of the season, toting three rushing touchdowns as well.

In CBS Sports’ fantasy rankings, he is positioned in the QB3-QB4 range, celebrated for his low turnover rate and dual-threat abilities. Transitioning to Indianapolis this year has rekindled his momentum, establishing him as a reliable fantasy quarterback as well as a leader in the Colts’ offense.

The optimizer additionally favors Giants RB Cam Skattebo ($6,000 on DraftKings and $6,200 on FanDuel). This rookie talent has demonstrated potential, rushing 48 times for 181 yards and netting two touchdowns thus far.

Skattebo has gained recognition as a fantasy breakout candidate due to expectations that he’ll become the lead back. Throughout his collegiate career, he amassed 4,386 rushing yards and caught 112 passes for 1,386 receiving yards, showcasing his versatile skill set. With multiple rookie accolades under his belt already, he’s making a significant impact in his first NFL season.

Formulating NFL DFS Lineups for Sunday

The DFS Optimizer will target several undervalued players poised for breakout performances this weekend. Identifying these key players could be crucial for winning tournaments or cash games. Check out the SportsLine site for complete details on optimal picks, strategies, and rankings from the DFS optimizer, which simulates every game 10,000 times.