Patriots vs. Bills Prediction and Odds
The Buffalo Bills are looking to maintain their undefeated status as they take on the New England Patriots in Sunday Night Football during NFL Week 5. Currently, Josh Allen and the Bills are among the only two unbeaten teams, while the Patriots, positioned second in the AFC East, stand at 2-2. Recently, Buffalo secured a 31-19 victory over the New Orleans Saints, whereas Drake Maye and the Patriots triumphed over the Carolina Panthers with a score of 42-13.
Kickoff is set for 8:20 p.m. ET at Highmark Stadium. The Bills are favored by 8.5 points, with an over/under of 49.5 total points. Oddly enough, the Bills are listed as -424 favorites (risking $424 to win $100), while the Patriots are the underdogs at +328 (betting $100 could yield a $328 return).
Before placing any bets on the Bills vs. Patriots match, take a look at what the SportsLine projection model predicts.
The model simulates each NFL game 10,000 times and has demonstrated a profit of over $7,000 for $100 players on its premier NFL picks since inception. It is currently riding a 39-20 streak on high-tier picks since 2024. Those who have followed its NFL betting choices through sportsbooks have enjoyed sizable returns.
Bills vs. Patriots Betting Information
| Spread | Bills -8.5 at DraftKings Sportsbook |
| Over/Under | 49.5 points |
| Money Line | Buffalo -424, New England +328 |
| Picks | See picks at SportsLine |
| Streaming | Fubo (try for free) |
Why the Patriots Can Cover
The Patriots have covered the odds in both clashes against the Bills in 2024, including a strong performance as a 14-point underdog during a Week 16 loss. With the return of Christian Gonzalez, their passing defense has improved, while they are limiting rushing opponents to an average of 77.5 yards per game. Maye has showcased his skills, averaging 11.9 yards per pass with two touchdowns without throwing any interceptions in Week 4.
Why the Bills Can Cover
Buffalo which also has a 2-2 against the spread mark this season, went 7-3 ATS at home last year and remains unbeaten at Highmark since facing the Chiefs in the AFC Divisional Playoff on January 21, 2024. Buffalo’s offensive gameplay has been exceptional, averaging 404 total yards and 33.3 points per game, while the run game has steadily delivered an average of 163.5 yards per outing. Josh Allen’s stats reinforce this performance, averaging 8.0 yards per pass combined with seven touchdowns and just one interception in his career against New England.
Making the Bills vs. Patriots Picks
For NFL Week 5, the model is inclined towards the ‘over’ on total points, and estimates one side of the spread will hit nearly 70% of the time. Discover the model’s predictions at SportsLine.
