Developing a successful NFL DFS strategy can take many forms, but one common approach is identifying top NFL DFS picks based on games with the highest projected point totals. The Cowboys vs. Panthers matchup stands out with an over/under of 49.5, making it a key focus for the week.
Other high-scoring matchups include 49ers vs. Buccaneers and Seahawks vs. Jaguars, both with an over/under of 47.5. Fantasy superstars like Dak Prescott, Christian McCaffrey, and Jonathan Taylor are expected to feature prominently in many lineups.
However, high-caliber players can strain salary caps, necessitating the search for value picks. Could it be time to consider quarterbacks like Daniel Jones or Baker Mayfield? As you finalize your lineups on platforms like DraftKings and FanDuel, visiting the SportsLine NFL DFS optimizer could provide you with essential insights.
Top NFL Week 6 DFS Picks
One standout pick is Dak Prescott, valued at $6,500 on DraftKings and $8,000 on FanDuel. Despite a challenging 2024, Prescott’s rebound in 2025 sees him with 1,356 passing yards and 10 touchdowns through five weeks, making him a favorable choice.
Players to Watch
- Dak Prescott
- Kyren Williams, currently priced at $6,300 on DraftKings, delivered a strong performance last season, and he continues to be a crucial part of the Rams’ offensive strategy.
Visit SportsLine to explore more optimal lineups and enhance your NFL fantasy experience.
