Developing a successful NFL DFS strategy can take many forms, but one of the most common approaches is focusing on games with the highest projected point totals when identifying top NFL DFS picks and building NFL DFS stacks. The highest over/under in the Week 7 NFL odds for the Sunday main slate is 54.5 in the Cowboys vs. Commanders matchup. Other potential high-scoring matchups on Sunday include Colts vs. Chargers (over/under of 48.5), Saints vs. Bears (over/under of 46.5), and Raiders vs. Chiefs (over/under of 45.5). Thus, you can expect stars like Dak Prescott, Jayden Daniels, Jonathan Taylor, Ladd McConkey, and Travis Kelce to be core players in many NFL DFS lineups.

Players of that caliber will set back your NFL DFS salary cap, forcing you to search for more potential NFL DFS sleepers and values. Should players like Daniel Jones or Justin Herbert find their way into your quarterback slot for Sunday? Will underperforming players like Saquon Barkley and Tua Tagovailoa finally live up to their price tags on NFL DFS sites? Before making any NFL DFS picks or locking in lineups on DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS lineup optimizer.

New users can also target the latest Underdog promo code, where they can pick at Underdog and get $100 in site credits after making a $5 wager:.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning lineups confidently with injury updates and player projections.

Now, SportsLine’s NFL DFS Optimizer has turned its attention to the Sunday 2025 NFL Week 6 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

New users can get $50 in Pick6 credits at DraftKings when they play $5.