Predictions and Odds for Ole Miss vs. South Carolina in Week 10 of College Football 2025
The seventh-ranked Ole Miss Rebels will host the South Carolina Gamecocks as they fight to keep their SEC championship dreams alive. A detailed overview of predictions and betting odds for this matchup.
The seventh-ranked Ole Miss Rebels aim to keep their hopes alive for the SEC championship with a crucial game against the South Carolina Gamecocks this Saturday. After suffering a 29-22 defeat to Alabama, South Carolina’s record stands at 3-5 with just one SEC win, while Ole Miss comes off a 34-26 triumph over Oklahoma and holds a 7-1 record in 2025.
Kickoff is set for 7 p.m. ET at Vaught-Hemingway Stadium, where Ole Miss enjoys a perfect home record so far this season. The Rebels previously defeated the Gamecocks 27-3 in their last encounter and are favored by 12.5 points, with an over/under set at 55.5 points.
The SportsLine Projection Model has performed over 10,000 simulations of every FBS matchup and has yielded significant betting profits, including an impressive 47-33 record on total points since the start of 2024. In this matchup, the model suggests that the total will remain under 49 points, and one side of the spread is projected to exceed 50% of the time.
Why Ole Miss can cover the spread
Senior quarterback Trinidad Chambliss has excelled this season, completing 61% of his passes for 1,864 yards and nine touchdowns. He also boasts a robust running game, supplementing his efforts with multiple rushing touchdowns.
Running back Kewan Lacy solidifies Ole Miss’s offensive strength, having tallied 696 rushing yards and 12 touchdowns. His consistency has been vital for the team’s scoring capability, especially in key matchups.
Why South Carolina can cover the spread
South Carolina’s dual-threat quarterback, LaNorris Sellers, maintains a notable passing efficiency, along with an agile running ability. His connection with wide receiver Vandrevius Jacobs has been impactful, as Jacobs has managed to secure significant yardage this season, enhancing the Gamecocks’ aerial attack.
How to make your picks
Exploit this matchup utilizing the insights from the SportsLine model, which has performed exceptionally well in predicting college football outcomes. For more detailed odds and trends, check the latest information available via SportsLine.
