Prediction and Betting Odds for Ole Miss vs. South Carolina in 2025
The matchup between the Ole Miss Rebels and the South Carolina Gamecocks is crucial for SEC standings as both teams head into Week 10 of the 2025 college football season.
In a critical SEC showdown, the #7 Ole Miss Rebels are aiming to maintain their position in the conference championship race against the South Carolina Gamecocks. After losing to Alabama with a score of 29-22, the Gamecocks come into this match with a three-game losing streak, while the Rebels are looking to extend their five-game home winning streak following their victory over Oklahoma (34-26).
Kickoff is scheduled for 7 p.m. ET at Vaught-Hemingway Stadium in Oxford, Mississippi. The latest betting line places Ole Miss as 12.5-point favorites with an over/under of 55.5 points according to SportsLine consensus. For comprehensive insights, you can check the college football predictions made by the SportsLine Projection Model.
Betting Details:
- Spread: Ole Miss -12.5
- Over/Under: 55.5 points
- Money Line: Ole Miss -483, South Carolina +368
Why Ole Miss Can Cover:
Senior quarterback Trinidad Chambliss has showcased remarkable skills, completing 61% of his passes for 1,864 yards and 9 touchdowns, complemented by solid rushing performance.
Why South Carolina Can Cover:
LaNorris Sellers, the sophomore quarterback for South Carolina, represents a dual threat, having completed over 60% of his passes alongside contributed rushing efforts.
For More Picks:
Explore further insights on which team to back by visiting SportsLine.
