The college basketball season for 2025-26 kicks off on November 3, featuring an exciting face-off between the defending champions, Florida Gators, and the Arizona Wildcats in the Hall of Fame Series at T-Mobile Arena in Las Vegas at 7 p.m. ET. The Gators are favored by 3.5 points with an over/under of 163.5.

Additional notable matchups include #8 BYU (-9.5) facing Villanova and #7 Michigan (-24.5) playing against Oakland. With many games unfolding throughout the day, here’s a look at the best betting insights.

Before making any bets, check out predictions and recommendations from SportsLine’s computer model that simulates each game 10,000 times.

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SportsLine’s model had a successful previous season with a record of 75-61 for top-rated college picks. It has now secured three confident bets:

• The model suggests wagering on Villanova (+9.5) to cover against #8 BYU. Villanova encounters a strong start under new head coach Kevin Willard, aiming to improve with new transfers alongside returning player Tyler Perkins. The matchup against BYU may pose challenges as they integrate freshman star AJ Dybantsa.

The model forecasts that this game will likely come down to the last moments, favoring Villanova to stay within the spread in over 60% of simulations.

See all betting recommendations from the model and make smart decisions this college basketball season!