NFL Week 10: Odds, Predictions, and Best Bets for Upcoming Games

The Week 10 NFL schedule showcases familiar rivalries with significant matchups, including the Rams facing off against the 49ers—currently, L.A. is the 4.5-point favorite on the road, according to recent NFL odds. In their earlier clash in October, the 49ers claimed victory with a close score of 26-23, while the Rams had dominated their last three encounters. ** **
The other divisional games include:

Bills at Dolphins (+9.5)
Texans visiting Jaguars (-1)
Saints against Panthers (-5.5)
Seahawks opposing Cardinals, the latter at home (-6.5)

Additionally, noteworthy non-divisional matchups are highlighted, including:

Steelers vs. Chargers (-3) on Sunday night
Eagles at Packers (-2.5) scheduled for Monday night.

Key Predictions for Week 10

Bucs vs. Patriots: The Bucs are favored by 2.5 points. New England is on a six-game winning streak but recently failed to cover the spread against Atlanta. Meanwhile, Tampa comes off a bye week, giving them a significant rest advantage, which could play a crucial role.
49ers vs. Rams: The model forecasts the 49ers to cover the spread against the Rams in more than 50% of simulations. With key performances from players like Christian McCaffrey, who recently set an NFL record, San Francisco seems poised to succeed in this match.

Interested in the Latest Odds?

For complete insights and predictions for every game in Week 10, visit SportsLine.