
USC vs. Northwestern Showdown: Predictions and Odds for the Big Ten Clash
The USC Trojans face off against the Northwestern Wildcats in a significant Big Ten matchup, with predictions and betting odds detailed.
USC vs. Northwestern Matchup
The 19th-ranked USC Trojans will strive to maintain their quest for the Big Ten title as they take on the Northwestern Wildcats this Friday evening. USC recently edged past Nebraska with a score of 21-17, while Northwestern faced a setback during their last game, falling to Nebraska 28-21. USC is currently positioned at 6-2 with a 4-1 Big Ten record, dominating their home games with a perfect 4-0 record in 2025, while Northwestern stands at 5-3 and holds a 3-2 record in the conference.
Kickoff is scheduled at 9 p.m. ET, and USC has never lost to Northwestern, leading the all-time series 5-0. Their most recent encounter was during the 1996 Rose Bowl, where USC triumphed with a score of 41-32. Currently, USC is favored by 14.5 points, with the total points over/under set at 50.5 according to SportsLine.
Key Players:
- Waymond Jordan (Running Back, USC) is doubtful due to an ankle injury.
- Jayden Maiava (Quarterback, USC) has thrown for 2,315 yards with an impressive 15 touchdowns this season.
- Preston Stone (Quarterback, Northwestern) has completed 126 of 216 passes this season, contributing significantly on the field.
- Caleb Komolafe (Running Back, Northwestern) is also having a strong season with 608 rushing yards to his name.
Betting Information
The predictions from the SportsLine Projection Model indicate a likely total of 55 points from this game, with one side of the spread predicted to be successful over 50% of simulation outcomes. Visit SportsLine now for insights for detailed analysis.


