One of the key matchups in Week 10 of the 2025 NFL season features NFC West rivals vying for the top of their division. The San Francisco 49ers (6-3) aim to complete a series sweep against the reigning division champions, the Los Angeles Rams (6-2), at 4:25 p.m. ET. San Francisco previously triumphed 26-23 in overtime during their Week 5 encounter in Los Angeles, while the Rams are currently riding a three-game winning streak.
For this Sunday’s game, leading sportsbooks have placed the rushing yards prop for Christian McCaffrey of San Francisco at 63.5 yards, with Puka Nacua from the Rams having his receiving yards prop at 91.5.
To get the most accurate insights before betting on McCaffrey, Nacua, or any prop for Week 10, consider the expert analysis from PropBetGuy, who boasts a +388 record on his last 19 NFL player prop picks. Below are some of his top prop picks:
Rachaad White Over 3.5 Receptions (-111, DraftKings)
Rachaad White is set to start for the Buccaneers, replacing the injured Bucky Irving. He has met or exceeded this receptions line in three of his last five games, and with expected increased targets against New England, where the defense has allowed the second-most targets to running backs, this looks favorable. Expect Baker Mayfield to utilize White as a primary target.
Devin Singletary Over 33.5 Rushing Yards (-112, FanDuel)
In a surprising Week 9 performance, Devin Singletary outsnapped his teammate Tyrone Tracy. With a favorable matchup against the Chicago Bears’ 25th-ranked run defense, and the possibility of poor weather affecting passing plays, this line could be an achievable goal.
Zach Charbonnet Under 49.5 Rushing + Receiving Yards (-114, FanDuel)
The rotations in the Seahawks backfield are quite complex, and many experts anticipate fading Zach Charbonnet. Having been under this total in six out of seven games, his snap share was also at its lowest last week, so it’s wiser to predict a reduced workload.
Find out further betting secrets on this match-up and position yourselves wisely for Week 10!
