
The NFL’s Week 10 schedule is packed with key division matchups, including a showdown between the Bills and Dolphins, as well as the Seahawks facing off against the Cardinals.
The Bills have shown dominance over the Dolphins, winning their last seven encounters, with their most recent victory being a decisive 31-21 win. For this upcoming game, the Bills are favored by 9 points according to the current NFL odds, and the over/under is set at 50 points—the highest on the schedule this week. With the Bills boasting the league’s top offense, averaging 385.5 yards per game, the model predicts a solid victory for Buffalo, covering the spread in 55% of simulations.
The model also predicts that the Seahawks are likely to cover the -6.5 spread at home against the Cardinals. In the matchup between the Rams and 49ers, the model suggests betting on the Under at 49.5 points.
For further insights, ensure to check out the comprehensive betting picks from SportsLine’s advanced model, which has proven successful across multiple games.
Week 10 Best Bets for Sunday, Nov. 9
- Bills (-9) against Dolphins
- Seahawks (-6.5) against Cardinals
- Under 49.5 points for 49ers vs. Rams
Combining these three picks into a parlay could yield impressive returns at +602 odds (bet $100 to win $602).
Are you looking for more Week 10 NFL predictions?
You can access all picks against the spread, totals, and moneyline choices for every NFL game this Week 10, supported by our extensive model simulations.


